diff --git a/packages/wxt/src/core/utils/__tests__/manifest.test.ts b/packages/wxt/src/core/utils/__tests__/manifest.test.ts
index a629f26d..42199c82 100644
--- a/packages/wxt/src/core/utils/__tests__/manifest.test.ts
+++ b/packages/wxt/src/core/utils/__tests__/manifest.test.ts
@@ -445,6 +445,28 @@ describe('Manifest Utils', () => {
 
         expect(actual.options_ui).toEqual(expected);
       });
+
+      it('should exclude open_in_tab for safari', async () => {
+        setFakeWxt({
+          config: {
+            manifestVersion: 3,
+            browser: 'safari',
+            outDir,
+          },
+        });
+        const buildOutput = fakeBuildOutput();
+
+        const { manifest: actual } = await generateManifest(
+          [options],
+          buildOutput,
+        );
+
+        expect(actual.options_ui).toEqual({
+          chrome_style: true,
+          page: 'options.html',
+        });
+        expect(actual.options_ui?.open_in_tab).toBeUndefined();
+      });
     });
 
     describe('background', () => {
diff --git a/packages/wxt/src/core/utils/manifest.ts b/packages/wxt/src/core/utils/manifest.ts
index fef39fea..6bcfaa15 100644
--- a/packages/wxt/src/core/utils/manifest.ts
+++ b/packages/wxt/src/core/utils/manifest.ts
@@ -333,7 +333,9 @@ function addEntrypoints(
   if (options) {
     const page = getEntrypointBundlePath(options, wxt.config.outDir, '.html');
     manifest.options_ui = {
-      open_in_tab: options.options.openInTab ?? false,
+      ...(wxt.config.browser !== 'safari' && {
+        open_in_tab: options.options.openInTab ?? false,
+      }),
       // @ts-expect-error: Not typed by @wxt-dev/browser, but supported by Firefox
       browser_style:
         wxt.config.browser === 'firefox'